ea0019oc3 | Young Endocrinologist prize session | SFEBES2009
Patel P
, Hardy R
, Gittoes N
, Rabbitt E
, Kindblom L
, Stewart P
, Cooper M
Osteosarcoma (OS) is an aggressive malignant tumour of osteoblasts occurring predominantly in children and young adults. Despite chemotherapy relapse is common and mortality remains ~50%. Non-transformed osteoblasts are highly sensitive to glucocorticoids which reduce proliferation and induce apoptosis. Previously, we observed that OS cells, but not normal osteoblasts, express 11beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2). This enzyme powerfully inactivates cortis...